| Home Team | Away Team | Home Pitcher | Away Pitcher | Stadium |
|---|---|---|---|---|
| Baltimore Orioles | Arizona Diamondbacks | TBD | TBD | Oriole Park at Camden Yards |
| St. Louis Cardinals | Cleveland Guardians | TBD | TBD | Busch Stadium |
| Minnesota Twins | Boston Red Sox | TBD | TBD | Target Field |
| Detroit Tigers | Kansas City Royals | TBD | TBD | Comerica Park |
| Pittsburgh Pirates | Washington Nationals | TBD | TBD | PNC Park |
| Cincinnati Reds | San Francisco Giants | TBD | TBD | Great American Ball Park |
| Philadelphia Phillies | Chicago Cubs | TBD | TBD | Citizens Bank Park |
| New York Yankees | Los Angeles Angels | TBD | TBD | Yankee Stadium |
| Atlanta Braves | Miami Marlins | TBD | TBD | Truist Park |
| Chicago White Sox | Tampa Bay Rays | TBD | TBD | Rate Field |
| Milwaukee Brewers | Toronto Blue Jays | TBD | TBD | American Family Field |
| Houston Astros | Colorado Rockies | TBD | TBD | Daikin Park |
| San Diego Padres | Seattle Mariners | TBD | TBD | Petco Park |
| Athletics | Texas Rangers | TBD | TBD | Sutter Health Park |
| Los Angeles Dodgers | New York Mets | TBD | TBD | UNIQLO Field at Dodger Stadium |